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Activation of Latent Human Immunodeficiency Virus by the Histone Deacetylase Inhibitor Panobinostat: A Pilot Study to Assess Effects on the Central Nervous System

In a substudy of a clinical trial, we assessed whether activation of latent human immunodeficiency virus (HIV) by the histone deacetylase inhibitor panobinostat had detrimental effects on the central nervous system (CNS). Adults infected with HIV received oral panobinostat 20 mg 3 times per week eve...

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Detalles Bibliográficos
Autores principales: Rasmussen, Thomas A., Tolstrup, Martin, Møller, Holger Jon, Brinkmann, Christel R., Olesen, Rikke, Erikstrup, Christian, Laursen, Alex L., Østergaard, Lars, Søgaard, Ole S.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2015
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4438909/
https://www.ncbi.nlm.nih.gov/pubmed/26034779
http://dx.doi.org/10.1093/ofid/ofv037