Effects of the Pathogenic Mutation A117V and the Protective Mutation H111S on the Folding and Aggregation of PrP106-126: Insights from Replica Exchange Molecular Dynamics Simulations

The fragment 106-126 of prion protein exhibits similar properties to full-length prion. Experiments have shown that the A117V mutation enhances the aggregation of PrP106-126, while the H111S mutation abolishes the assembly. However, the mechanism of the change in the aggregation behavior of PrP106-1...

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Detalles Bibliográficos
Autores principales: Ning, Lulu, Pan, Dabo, Zhang, Yan, Wang, Shaopeng, Liu, Huanxiang, Yao, Xiaojun
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2015
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4439087/
https://www.ncbi.nlm.nih.gov/pubmed/25993001
http://dx.doi.org/10.1371/journal.pone.0125899

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4439087/
https://www.ncbi.nlm.nih.gov/pubmed/25993001
http://dx.doi.org/10.1371/journal.pone.0125899

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