Pigment Epithelium-Derived Factor (PEDF) Expression Induced by EGFRvIII Promotes Self-renewal and Tumor Progression of Glioma Stem Cells

Epidermal growth factor receptor variant III (EGFRvIII) has been associated with glioma stemness, but the direct molecular mechanism linking the two is largely unknown. Here, we show that EGFRvIII induces the expression and secretion of pigment epithelium-derived factor (PEDF) via activation of sign...

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Detalles Bibliográficos
Autores principales: Yin, Jinlong, Park, Gunwoo, Kim, Tae Hoon, Hong, Jun Hee, Kim, Youn-Jae, Jin, Xiong, Kang, Sangjo, Jung, Ji-Eun, Kim, Jeong-Yub, Yun, Hyeongsun, Lee, Jeong Eun, Kim, Minkyung, Chung, Junho, Kim, Hyunggee, Nakano, Ichiro, Gwak, Ho-Shin, Yoo, Heon, Yoo, Byong Chul, Kim, Jong Heon, Hur, Eun-Mi, Lee, Jeongwu, Lee, Seung-Hoon, Park, Myung-Jin, Park, Jong Bae
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2015
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4439169/
https://www.ncbi.nlm.nih.gov/pubmed/25992628
http://dx.doi.org/10.1371/journal.pbio.1002152

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4439169/
https://www.ncbi.nlm.nih.gov/pubmed/25992628
http://dx.doi.org/10.1371/journal.pbio.1002152

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