Thymic regulatory T cell niche size is dictated by limiting interleukin 2 from antigen-bearing dendritic cells and feedback competition

Thymic regulatory T (T(reg)) cell production requires interleukin 2 (IL-2) and agonist TCR ligands, and is controlled by competition for a limited developmental niche, but the thymic sources of IL-2 and the factors that limit access to the niche are poorly understood. Here we show that IL-2 produced...

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Detalles Bibliográficos
Autores principales: Weist, Brian M., Kurd, Nadia, Boussier, Jeremy, Chan, Shiao Wei, Robey, Ellen A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2015
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4439282/
https://www.ncbi.nlm.nih.gov/pubmed/25939026
http://dx.doi.org/10.1038/ni.3171

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4439282/
https://www.ncbi.nlm.nih.gov/pubmed/25939026
http://dx.doi.org/10.1038/ni.3171

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