Thymic regulatory T cell niche size is dictated by limiting interleukin 2 from antigen-bearing dendritic cells and feedback competition

Thymic regulatory T (T(reg)) cell production requires interleukin 2 (IL-2) and agonist TCR ligands, and is controlled by competition for a limited developmental niche, but the thymic sources of IL-2 and the factors that limit access to the niche are poorly understood. Here we show that IL-2 produced...

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Autores principales: Weist, Brian M., Kurd, Nadia, Boussier, Jeremy, Chan, Shiao Wei, Robey, Ellen A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2015
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4439282/
https://www.ncbi.nlm.nih.gov/pubmed/25939026
http://dx.doi.org/10.1038/ni.3171
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author Weist, Brian M.
Kurd, Nadia
Boussier, Jeremy
Chan, Shiao Wei
Robey, Ellen A.
author_facet Weist, Brian M.
Kurd, Nadia
Boussier, Jeremy
Chan, Shiao Wei
Robey, Ellen A.
author_sort Weist, Brian M.
collection PubMed
description Thymic regulatory T (T(reg)) cell production requires interleukin 2 (IL-2) and agonist TCR ligands, and is controlled by competition for a limited developmental niche, but the thymic sources of IL-2 and the factors that limit access to the niche are poorly understood. Here we show that IL-2 produced by antigen-bearing dendritic cells plays a key role in T(reg) cell development, and that existing T(reg) cells limit new T(reg) cell development by competing for IL-2. . Our data suggest that antigen-presenting cells that can provide both IL-2 and a TCR ligand comprise the thymic niche, and that competition by existing T(reg) cells for a limited supply of IL-2 provides negative feedback for new T(reg) cell production.
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spelling pubmed-44392822015-12-01 Thymic regulatory T cell niche size is dictated by limiting interleukin 2 from antigen-bearing dendritic cells and feedback competition Weist, Brian M. Kurd, Nadia Boussier, Jeremy Chan, Shiao Wei Robey, Ellen A. Nat Immunol Article Thymic regulatory T (T(reg)) cell production requires interleukin 2 (IL-2) and agonist TCR ligands, and is controlled by competition for a limited developmental niche, but the thymic sources of IL-2 and the factors that limit access to the niche are poorly understood. Here we show that IL-2 produced by antigen-bearing dendritic cells plays a key role in T(reg) cell development, and that existing T(reg) cells limit new T(reg) cell development by competing for IL-2. . Our data suggest that antigen-presenting cells that can provide both IL-2 and a TCR ligand comprise the thymic niche, and that competition by existing T(reg) cells for a limited supply of IL-2 provides negative feedback for new T(reg) cell production. 2015-05-04 2015-06 /pmc/articles/PMC4439282/ /pubmed/25939026 http://dx.doi.org/10.1038/ni.3171 Text en http://www.nature.com/authors/editorial_policies/license.html#terms Users may view, print, copy, and download text and data-mine the content in such documents, for the purposes of academic research, subject always to the full Conditions of use:http://www.nature.com/authors/editorial_policies/license.html#terms
spellingShingle Article
Weist, Brian M.
Kurd, Nadia
Boussier, Jeremy
Chan, Shiao Wei
Robey, Ellen A.
Thymic regulatory T cell niche size is dictated by limiting interleukin 2 from antigen-bearing dendritic cells and feedback competition
title Thymic regulatory T cell niche size is dictated by limiting interleukin 2 from antigen-bearing dendritic cells and feedback competition
title_full Thymic regulatory T cell niche size is dictated by limiting interleukin 2 from antigen-bearing dendritic cells and feedback competition
title_fullStr Thymic regulatory T cell niche size is dictated by limiting interleukin 2 from antigen-bearing dendritic cells and feedback competition
title_full_unstemmed Thymic regulatory T cell niche size is dictated by limiting interleukin 2 from antigen-bearing dendritic cells and feedback competition
title_short Thymic regulatory T cell niche size is dictated by limiting interleukin 2 from antigen-bearing dendritic cells and feedback competition
title_sort thymic regulatory t cell niche size is dictated by limiting interleukin 2 from antigen-bearing dendritic cells and feedback competition
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4439282/
https://www.ncbi.nlm.nih.gov/pubmed/25939026
http://dx.doi.org/10.1038/ni.3171
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