Species differential regulation of COX2 can be described by an NFκB-dependent logic AND gate

Cyclooxygenase 2 (COX2), a key regulatory enzyme of the prostaglandin/eicosanoid pathway, is an important target for anti-inflammatory therapy. It is highly induced by pro-inflammatory cytokines in a Nuclear factor kappa B (NFκB)-dependent manner. However, the mechanisms determining the amplitude an...

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Detalles Bibliográficos
Autores principales: Nguyen, Lan K., Cavadas, Miguel A. S., Kholodenko, Boris N., Frank, Till D., Cheong, Alex
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Springer Basel 2015
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4439527/
https://www.ncbi.nlm.nih.gov/pubmed/25697863
http://dx.doi.org/10.1007/s00018-015-1850-1

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4439527/
https://www.ncbi.nlm.nih.gov/pubmed/25697863
http://dx.doi.org/10.1007/s00018-015-1850-1

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