Novel roles for protein disulphide isomerase in disease states: a double edged sword?

Protein disulphide isomerase (PDI) is a multifunctional redox chaperone of the endoplasmic reticulum (ER). Since it was first discovered 40 years ago the functions ascribed to PDI have evolved significantly and recent studies have recognized its distinct functions, with adverse as well as protective...

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Autores principales: Parakh, Sonam, Atkin, Julie D.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2015
Materias:
Chemistry
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4439577/
https://www.ncbi.nlm.nih.gov/pubmed/26052512
http://dx.doi.org/10.3389/fcell.2015.00030
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author Parakh, Sonam
Atkin, Julie D.
author_facet Parakh, Sonam
Atkin, Julie D.
author_sort Parakh, Sonam
collection PubMed
description Protein disulphide isomerase (PDI) is a multifunctional redox chaperone of the endoplasmic reticulum (ER). Since it was first discovered 40 years ago the functions ascribed to PDI have evolved significantly and recent studies have recognized its distinct functions, with adverse as well as protective effects in disease. Furthermore, post translational modifications of PDI abrogate its normal functional roles in specific disease states. This review focusses on recent studies that have identified novel functions for PDI relevant to specific diseases.
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spelling pubmed-44395772015-06-05 Novel roles for protein disulphide isomerase in disease states: a double edged sword? Parakh, Sonam Atkin, Julie D. Front Cell Dev Biol Chemistry Protein disulphide isomerase (PDI) is a multifunctional redox chaperone of the endoplasmic reticulum (ER). Since it was first discovered 40 years ago the functions ascribed to PDI have evolved significantly and recent studies have recognized its distinct functions, with adverse as well as protective effects in disease. Furthermore, post translational modifications of PDI abrogate its normal functional roles in specific disease states. This review focusses on recent studies that have identified novel functions for PDI relevant to specific diseases. Frontiers Media S.A. 2015-05-21 /pmc/articles/PMC4439577/ /pubmed/26052512 http://dx.doi.org/10.3389/fcell.2015.00030 Text en Copyright © 2015 Parakh and Atkin. http://creativecommons.org/licenses/by/4.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Chemistry
Parakh, Sonam
Atkin, Julie D.
Novel roles for protein disulphide isomerase in disease states: a double edged sword?
title Novel roles for protein disulphide isomerase in disease states: a double edged sword?
title_full Novel roles for protein disulphide isomerase in disease states: a double edged sword?
title_fullStr Novel roles for protein disulphide isomerase in disease states: a double edged sword?
title_full_unstemmed Novel roles for protein disulphide isomerase in disease states: a double edged sword?
title_short Novel roles for protein disulphide isomerase in disease states: a double edged sword?
title_sort novel roles for protein disulphide isomerase in disease states: a double edged sword?
topic Chemistry
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4439577/
https://www.ncbi.nlm.nih.gov/pubmed/26052512
http://dx.doi.org/10.3389/fcell.2015.00030
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