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PI3K mutations in breast cancer: prognostic and therapeutic implications
The PI3K pathway is the most frequently enhanced oncogenic pathway in breast cancer. Among mechanisms of PI3K enhancement, PIK3CA mutations are most frequently (∼30%) observed, along with protein loss of PTEN. Since the first discovery of PIK3CA mutations in solid malignancies in 2004, numerous stud...
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
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Dove Medical Press
2015
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| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4440424/ https://www.ncbi.nlm.nih.gov/pubmed/26028978 http://dx.doi.org/10.2147/BCTT.S60696 |