Evaluating early administration of the hydroxymethylglutaryl-CoA reductase inhibitor simvastatin in the prevention and treatment of delirium in critically ill ventilated patients (MoDUS trial): study protocol for a randomized controlled trial

BACKGROUND: The incidence of delirium in ventilated patients is estimated at up to 82%, and it is associated with longer intensive care and hospital stays, and long-term cognitive impairment and mortality. The pathophysiology of delirium has been linked with inflammation and neuronal apoptosis. Simv...

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Detalles Bibliográficos
Autores principales: Casarin, Annalisa, McAuley, Daniel F, Alce, Timothy M, Zhao, Xiaobei, Ely, E Wesley, Jackson, Jim C, McDowell, Cliona, Agus, Ashley, Murphy, Lynn, Page, Valerie J
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2015
Materias:
Study Protocol
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4440514/
https://www.ncbi.nlm.nih.gov/pubmed/25982544
http://dx.doi.org/10.1186/s13063-015-0731-0

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4440514/
https://www.ncbi.nlm.nih.gov/pubmed/25982544
http://dx.doi.org/10.1186/s13063-015-0731-0

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