New High Affinity Monoclonal Antibodies Recognize Non-Overlapping Epitopes On Mesothelin For Monitoring And Treating Mesothelioma

Mesothelin is an emerging cell surface target in mesothelioma and other solid tumors. Most antibody drug candidates recognize highly immunogenic Region I (296–390) on mesothelin. Here, we report a group of high-affinity non-Region I rabbit monoclonal antibodies. These antibodies do not compete for m...

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Detalles Bibliográficos
Autores principales: Zhang, Yi-Fan, Phung, Yen, Gao, Wei, Kawa, Seiji, Hassan, Raffit, Pastan, Ira, Ho, Mitchell
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2015
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4440525/
https://www.ncbi.nlm.nih.gov/pubmed/25996440
http://dx.doi.org/10.1038/srep09928

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4440525/
https://www.ncbi.nlm.nih.gov/pubmed/25996440
http://dx.doi.org/10.1038/srep09928

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