The Engineering of a Novel Ligand in gH Confers to HSV an Expanded Tropism Independent of gD Activation by Its Receptors

Herpes simplex virus (HSV) enters cells by means of four essential glycoproteins - gD, gH/gL, gB, activated in a cascade fashion by gD binding to one of its receptors, nectin1 and HVEM. We report that the engineering in gH of a heterologous ligand – a single-chain antibody (scFv) to the cancer-speci...

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Detalles Bibliográficos
Autores principales: Gatta, Valentina, Petrovic, Biljana, Campadelli-Fiume, Gabriella
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2015
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4440635/
https://www.ncbi.nlm.nih.gov/pubmed/25996983
http://dx.doi.org/10.1371/journal.ppat.1004907

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4440635/
https://www.ncbi.nlm.nih.gov/pubmed/25996983
http://dx.doi.org/10.1371/journal.ppat.1004907

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