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The Engineering of a Novel Ligand in gH Confers to HSV an Expanded Tropism Independent of gD Activation by Its Receptors

Herpes simplex virus (HSV) enters cells by means of four essential glycoproteins - gD, gH/gL, gB, activated in a cascade fashion by gD binding to one of its receptors, nectin1 and HVEM. We report that the engineering in gH of a heterologous ligand – a single-chain antibody (scFv) to the cancer-speci...

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Detalles Bibliográficos
Autores principales:	Gatta, Valentina, Petrovic, Biljana, Campadelli-Fiume, Gabriella
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Public Library of Science 2015
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4440635/ https://www.ncbi.nlm.nih.gov/pubmed/25996983 http://dx.doi.org/10.1371/journal.ppat.1004907

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