Neutrophil-Derived MMP-8 Drives AMPK-Dependent Matrix Destruction in Human Pulmonary Tuberculosis

Pulmonary cavities, the hallmark of tuberculosis (TB), are characterized by high mycobacterial load and perpetuate the spread of M. tuberculosis. The mechanism of matrix destruction resulting in cavitation is not well defined. Neutrophils are emerging as key mediators of TB immunopathology and their...

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Detalles Bibliográficos
Autores principales: Ong, Catherine W. M., Elkington, Paul T., Brilha, Sara, Ugarte-Gil, Cesar, Tome-Esteban, Maite T., Tezera, Liku B., Pabisiak, Przemyslaw J., Moores, Rachel C., Sathyamoorthy, Tarangini, Patel, Vimal, Gilman, Robert H., Porter, Joanna C., Friedland, Jon S.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2015
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4440706/
https://www.ncbi.nlm.nih.gov/pubmed/25996154
http://dx.doi.org/10.1371/journal.ppat.1004917

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4440706/
https://www.ncbi.nlm.nih.gov/pubmed/25996154
http://dx.doi.org/10.1371/journal.ppat.1004917

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