Myopathic Lamin Mutations Cause Reductive Stress and Activate the Nrf2/Keap-1 Pathway

Mutations in the human LMNA gene cause muscular dystrophy by mechanisms that are incompletely understood. The LMNA gene encodes A-type lamins, intermediate filaments that form a network underlying the inner nuclear membrane, providing structural support for the nucleus and organizing the genome. To...

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Detalles Bibliográficos
Autores principales: Dialynas, George, Shrestha, Om K., Ponce, Jessica M., Zwerger, Monika, Thiemann, Dylan A., Young, Grant H., Moore, Steven A., Yu, Liping, Lammerding, Jan, Wallrath, Lori L.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2015
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4440730/
https://www.ncbi.nlm.nih.gov/pubmed/25996830
http://dx.doi.org/10.1371/journal.pgen.1005231

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4440730/
https://www.ncbi.nlm.nih.gov/pubmed/25996830
http://dx.doi.org/10.1371/journal.pgen.1005231

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