Design and Structural Requirements of the Potent and Safe TLR-9 Agonistic Immunomodulator MGN1703

Single-stranded oligodeoxynucleotides (ODN), containing nonmethylated cytosine–guanine motifs (CpG ODN), are recognized by the innate immune system as “danger signals.” CpG ODN are efficacious immunomodulators but require phosphorothioate (PT) or other backbone modifications for metabolic stability,...

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Detalles Bibliográficos
Autores principales: Schmidt, Manuel, Hagner, Nicole, Marco, Alberto, König-Merediz, Sven A., Schroff, Matthias, Wittig, Burghardt
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Mary Ann Liebert, Inc. 2015
Materias:
Original Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4440985/
https://www.ncbi.nlm.nih.gov/pubmed/25826686
http://dx.doi.org/10.1089/nat.2015.0533

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4440985/
https://www.ncbi.nlm.nih.gov/pubmed/25826686
http://dx.doi.org/10.1089/nat.2015.0533

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