High-titer foamy virus vector transduction and integration sites of human CD34(+) cell–derived SCID-repopulating cells

Foamy virus (FV) vectors are promising tools for gene therapy, but low titer is a major challenge for large-scale clinical trials. Here, we increased FV vector titer 50-fold by constructing novel vector plasmids and using polyethylenimine-mediated transfection. FV and lentiviral (LV) vectors were us...

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Detalles Bibliográficos
Autores principales: Nasimuzzaman, Md, Kim, Yoon-Sang, Wang, Yong-Dong, Persons, Derek A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2014
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4441046/
https://www.ncbi.nlm.nih.gov/pubmed/26015964
http://dx.doi.org/10.1038/mtm.2014.20

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4441046/
https://www.ncbi.nlm.nih.gov/pubmed/26015964
http://dx.doi.org/10.1038/mtm.2014.20

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