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Regulation of recombination at yeast nuclear pores controls repair and triplet repeat stability

Secondary structure-forming DNA sequences such as CAG repeats interfere with replication and repair, provoking fork stalling, chromosome fragility, and recombination. In budding yeast, we found that expanded CAG repeats are more likely than unexpanded repeats to localize to the nuclear periphery. Th...

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Detalles Bibliográficos
Autores principales: Su, Xiaofeng A., Dion, Vincent, Gasser, Susan M., Freudenreich, Catherine H.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Cold Spring Harbor Laboratory Press 2015
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4441049/
https://www.ncbi.nlm.nih.gov/pubmed/25940904
http://dx.doi.org/10.1101/gad.256404.114