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Biosynthesis and regulation of terpenoid indole alkaloids in Catharanthus roseus
Catharanthus roseus produces a wide range of terpenoid indole alkaloids (TIA). Many of them, such as vinblastine and vincristine, have significant bioactivity. They are valuable chemotherapy drugs used in combination with other drugs to treat lymphoma and leukemia. The TIA biosynthetic pathway has b...
Autores principales: | , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Medknow Publications & Media Pvt Ltd
2015
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Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4441158/ https://www.ncbi.nlm.nih.gov/pubmed/26009689 http://dx.doi.org/10.4103/0973-7847.156323 |
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author | Zhu, Jianhua Wang, Mingxuan Wen, Wei Yu, Rongmin |
author_facet | Zhu, Jianhua Wang, Mingxuan Wen, Wei Yu, Rongmin |
author_sort | Zhu, Jianhua |
collection | PubMed |
description | Catharanthus roseus produces a wide range of terpenoid indole alkaloids (TIA). Many of them, such as vinblastine and vincristine, have significant bioactivity. They are valuable chemotherapy drugs used in combination with other drugs to treat lymphoma and leukemia. The TIA biosynthetic pathway has been investigated for many years, for scientific interest and for their potential in manufacturing applications, to fulfill the market demand. In this review, the progress and perspective of C. roseus TIA biosynthesis and its regulating enzymes are described. In addition, the culture condition, hormones, signaling molecules, precursor feeding on the accumulation of TIA, and gene expression are also evaluated and discussed. |
format | Online Article Text |
id | pubmed-4441158 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2015 |
publisher | Medknow Publications & Media Pvt Ltd |
record_format | MEDLINE/PubMed |
spelling | pubmed-44411582015-05-25 Biosynthesis and regulation of terpenoid indole alkaloids in Catharanthus roseus Zhu, Jianhua Wang, Mingxuan Wen, Wei Yu, Rongmin Pharmacogn Rev Review Article Catharanthus roseus produces a wide range of terpenoid indole alkaloids (TIA). Many of them, such as vinblastine and vincristine, have significant bioactivity. They are valuable chemotherapy drugs used in combination with other drugs to treat lymphoma and leukemia. The TIA biosynthetic pathway has been investigated for many years, for scientific interest and for their potential in manufacturing applications, to fulfill the market demand. In this review, the progress and perspective of C. roseus TIA biosynthesis and its regulating enzymes are described. In addition, the culture condition, hormones, signaling molecules, precursor feeding on the accumulation of TIA, and gene expression are also evaluated and discussed. Medknow Publications & Media Pvt Ltd 2015 /pmc/articles/PMC4441158/ /pubmed/26009689 http://dx.doi.org/10.4103/0973-7847.156323 Text en Copyright: © Pharmacognosy Reviews http://creativecommons.org/licenses/by-nc-sa/3.0 This is an open-access article distributed under the terms of the Creative Commons Attribution-Noncommercial-Share Alike 3.0 Unported, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | Review Article Zhu, Jianhua Wang, Mingxuan Wen, Wei Yu, Rongmin Biosynthesis and regulation of terpenoid indole alkaloids in Catharanthus roseus |
title | Biosynthesis and regulation of terpenoid indole alkaloids in Catharanthus roseus |
title_full | Biosynthesis and regulation of terpenoid indole alkaloids in Catharanthus roseus |
title_fullStr | Biosynthesis and regulation of terpenoid indole alkaloids in Catharanthus roseus |
title_full_unstemmed | Biosynthesis and regulation of terpenoid indole alkaloids in Catharanthus roseus |
title_short | Biosynthesis and regulation of terpenoid indole alkaloids in Catharanthus roseus |
title_sort | biosynthesis and regulation of terpenoid indole alkaloids in catharanthus roseus |
topic | Review Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4441158/ https://www.ncbi.nlm.nih.gov/pubmed/26009689 http://dx.doi.org/10.4103/0973-7847.156323 |
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