TSC1 Promotes B Cell Maturation but Is Dispensable for Germinal Center Formation

Accumulating evidence indicates that the tuberous sclerosis complex 1 (TSC1), a tumor suppressor that acts by inhibiting mTOR signaling, plays an important role in the immune system. We report here that TSC1 differentially regulates mTOR complex 1 (mTORC1) and mTORC2/Akt signaling in B cells. TSC1 d...

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Detalles Bibliográficos
Autores principales: Ci, Xinxin, Kuraoka, Masayuki, Wang, Hongxia, Carico, Zachary, Hopper, Kristen, Shin, Jinwook, Deng, Xuming, Qiu, Yirong, Unniraman, Shyam, Kelsoe, Garnett, Zhong, Xiao-Ping
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2015
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4441391/
https://www.ncbi.nlm.nih.gov/pubmed/26000908
http://dx.doi.org/10.1371/journal.pone.0127527

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4441391/
https://www.ncbi.nlm.nih.gov/pubmed/26000908
http://dx.doi.org/10.1371/journal.pone.0127527

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