Monoallelic Loss of the Imprinted Gene Grb10 Promotes Tumor Formation in Irradiated Nf1(+/-) Mice

Imprinted genes are expressed from only one parental allele and heterozygous loss involving the expressed allele is sufficient to produce complete loss of protein expression. Genetic alterations are common in tumorigenesis but the role of imprinted genes in this process is not well understood. In ea...

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Detalles Bibliográficos
Autores principales: Mroue, Rana, Huang, Brian, Braunstein, Steve, Firestone, Ari J., Nakamura, Jean L.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2015
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4441450/
https://www.ncbi.nlm.nih.gov/pubmed/26000738
http://dx.doi.org/10.1371/journal.pgen.1005235

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4441450/
https://www.ncbi.nlm.nih.gov/pubmed/26000738
http://dx.doi.org/10.1371/journal.pgen.1005235

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