Rescue of DNA-PK Signaling and T-Cell Differentiation by Targeted Genome Editing in a prkdc Deficient iPSC Disease Model

In vitro disease modeling based on induced pluripotent stem cells (iPSCs) provides a powerful system to study cellular pathophysiology, especially in combination with targeted genome editing and protocols to differentiate iPSCs into affected cell types. In this study, we established zinc-finger nucl...

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Detalles Bibliográficos
Autores principales: Rahman, Shamim H., Kuehle, Johannes, Reimann, Christian, Mlambo, Tafadzwa, Alzubi, Jamal, Maeder, Morgan L., Riedel, Heimo, Fisch, Paul, Cantz, Tobias, Rudolph, Cornelia, Mussolino, Claudio, Joung, J. Keith, Schambach, Axel, Cathomen, Toni
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2015
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4441453/
https://www.ncbi.nlm.nih.gov/pubmed/26000857
http://dx.doi.org/10.1371/journal.pgen.1005239

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4441453/
https://www.ncbi.nlm.nih.gov/pubmed/26000857
http://dx.doi.org/10.1371/journal.pgen.1005239

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