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Quantifying the Tendency of Therapeutic Target Proteins to Bind Promiscuous or Selective Compounds
The ability of target proteins to bind structurally diverse compounds and compounds with different degrees of promiscuity (multi-target activity) was systematically assessed on the basis of currently available activity data and target annotations. Intuitive first- and second-order target promiscuity...
| Autores principales: | , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
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Public Library of Science
2015
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| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4441477/ https://www.ncbi.nlm.nih.gov/pubmed/26000736 http://dx.doi.org/10.1371/journal.pone.0126838 |