Improved survival of patients with hypermutation in uterine serous carcinoma

• Uterine serous carcinoma (USC) is an aggressive subtype of endometrial cancer. • Mutations in DNA polymerase ε gene (POLE) are detected in a subset of USC and confer a strong mutator phenotype. • USC patients diagnosed with POLE mutations experience a significantly better prognosis.

Detalles Bibliográficos
Autores principales: Santin, Alessandro D., Bellone, Stefania, Centritto, Floriana, Schlessinger, Joseph, Lifton, Richard
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2015
Materias:
Short Communication
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4442647/
https://www.ncbi.nlm.nih.gov/pubmed/26076146
http://dx.doi.org/10.1016/j.gore.2015.01.005

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4442647/
https://www.ncbi.nlm.nih.gov/pubmed/26076146
http://dx.doi.org/10.1016/j.gore.2015.01.005

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