Improved survival of patients with hypermutation in uterine serous carcinoma

• Uterine serous carcinoma (USC) is an aggressive subtype of endometrial cancer. • Mutations in DNA polymerase ε gene (POLE) are detected in a subset of USC and confer a strong mutator phenotype. • USC patients diagnosed with POLE mutations experience a significantly better prognosis.

Detalles Bibliográficos
Autores principales: Santin, Alessandro D., Bellone, Stefania, Centritto, Floriana, Schlessinger, Joseph, Lifton, Richard
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2015
Materias:
Short Communication
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4442647/
https://www.ncbi.nlm.nih.gov/pubmed/26076146
http://dx.doi.org/10.1016/j.gore.2015.01.005
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author Santin, Alessandro D.
Bellone, Stefania
Centritto, Floriana
Schlessinger, Joseph
Lifton, Richard
author_facet Santin, Alessandro D.
Bellone, Stefania
Centritto, Floriana
Schlessinger, Joseph
Lifton, Richard
author_sort Santin, Alessandro D.
collection PubMed
description • Uterine serous carcinoma (USC) is an aggressive subtype of endometrial cancer. • Mutations in DNA polymerase ε gene (POLE) are detected in a subset of USC and confer a strong mutator phenotype. • USC patients diagnosed with POLE mutations experience a significantly better prognosis.
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spelling pubmed-44426472015-06-05 Improved survival of patients with hypermutation in uterine serous carcinoma Santin, Alessandro D. Bellone, Stefania Centritto, Floriana Schlessinger, Joseph Lifton, Richard Gynecol Oncol Rep Short Communication • Uterine serous carcinoma (USC) is an aggressive subtype of endometrial cancer. • Mutations in DNA polymerase ε gene (POLE) are detected in a subset of USC and confer a strong mutator phenotype. • USC patients diagnosed with POLE mutations experience a significantly better prognosis. Elsevier 2015-01-24 /pmc/articles/PMC4442647/ /pubmed/26076146 http://dx.doi.org/10.1016/j.gore.2015.01.005 Text en © 2015 The Authors http://creativecommons.org/licenses/by-nc-nd/4.0/ This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/).
spellingShingle Short Communication
Santin, Alessandro D.
Bellone, Stefania
Centritto, Floriana
Schlessinger, Joseph
Lifton, Richard
Improved survival of patients with hypermutation in uterine serous carcinoma
title Improved survival of patients with hypermutation in uterine serous carcinoma
title_full Improved survival of patients with hypermutation in uterine serous carcinoma
title_fullStr Improved survival of patients with hypermutation in uterine serous carcinoma
title_full_unstemmed Improved survival of patients with hypermutation in uterine serous carcinoma
title_short Improved survival of patients with hypermutation in uterine serous carcinoma
title_sort improved survival of patients with hypermutation in uterine serous carcinoma
topic Short Communication
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4442647/
https://www.ncbi.nlm.nih.gov/pubmed/26076146
http://dx.doi.org/10.1016/j.gore.2015.01.005
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