Contribution of a Low-Barrier Hydrogen Bond to Catalysis Is Not Significant in Ketosteroid Isomerase

Low-barrier hydrogen bonds (LBHBs) have been proposed to have important influences on the enormous reaction rate increases achieved by many enzymes. Δ(5)-3-ketosteroid isomerase (KSI) catalyzes the allylic isomerization of Δ(5)-3-ketosteroid to its conjugated Δ(4)-isomers at a rate that approaches t...

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Detalles Bibliográficos
Autores principales: Jang, Do Soo, Choi, Gildon, Cha, Hyung Jin, Shin, Sejeong, Hong, Bee Hak, Lee, Hyeong Ju, Lee, Hee Cheon, Choi, Kwan Yong
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Korean Society for Molecular and Cellular Biology 2015
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4443282/
https://www.ncbi.nlm.nih.gov/pubmed/25947291
http://dx.doi.org/10.14348/molcells.2015.2266

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4443282/
https://www.ncbi.nlm.nih.gov/pubmed/25947291
http://dx.doi.org/10.14348/molcells.2015.2266

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