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Brain-derived neurotrophic factor is required for axonal growth of selective groups of neurons in the arcuate nucleus

OBJECTIVE: Brain-derived neurotrophic factor (BDNF) is a potent regulator of neuronal development, and the Bdnf gene produces two populations of transcripts with either a short or long 3′ untranslated region (3′ UTR). Deficiencies in BDNF signaling have been shown to cause severe obesity in humans;...

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Detalles Bibliográficos
Autores principales: Liao, Guey-Ying, Bouyer, Karine, Kamitakahara, Anna, Sahibzada, Niaz, Wang, Chien-Hua, Rutlin, Michael, Simerly, Richard B., Xu, Baoji
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2015
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4443292/
https://www.ncbi.nlm.nih.gov/pubmed/26042201
http://dx.doi.org/10.1016/j.molmet.2015.03.003