Obesity in a model of gpx4 haploinsufficiency uncovers a causal role for lipid-derived aldehydes in human metabolic disease and cardiomyopathy

OBJECTIVE: Lipid peroxides and their reactive aldehyde derivatives (LPPs) have been linked to obesity-related pathologies, but whether they have a causal role has remained unclear. Glutathione peroxidase 4 (GPx4) is a selenoenzyme that selectively neutralizes lipid hydroperoxides, and human gpx4 gen...

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Detalles Bibliográficos
Autores principales: Katunga, Lalage A., Gudimella, Preeti, Efird, Jimmy T., Abernathy, Scott, Mattox, Taylor A., Beatty, Cherese, Darden, Timothy M., Thayne, Kathleen A., Alwair, Hazaim, Kypson, Alan P., Virag, Jitka A., Anderson, Ethan J.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2015
Materias:
Original Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4443294/
https://www.ncbi.nlm.nih.gov/pubmed/26042203
http://dx.doi.org/10.1016/j.molmet.2015.04.001

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4443294/
https://www.ncbi.nlm.nih.gov/pubmed/26042203
http://dx.doi.org/10.1016/j.molmet.2015.04.001

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