Cargando…

Obesity in a model of gpx4 haploinsufficiency uncovers a causal role for lipid-derived aldehydes in human metabolic disease and cardiomyopathy

OBJECTIVE: Lipid peroxides and their reactive aldehyde derivatives (LPPs) have been linked to obesity-related pathologies, but whether they have a causal role has remained unclear. Glutathione peroxidase 4 (GPx4) is a selenoenzyme that selectively neutralizes lipid hydroperoxides, and human gpx4 gen...

Descripción completa

Detalles Bibliográficos
Autores principales:	Katunga, Lalage A., Gudimella, Preeti, Efird, Jimmy T., Abernathy, Scott, Mattox, Taylor A., Beatty, Cherese, Darden, Timothy M., Thayne, Kathleen A., Alwair, Hazaim, Kypson, Alan P., Virag, Jitka A., Anderson, Ethan J.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Elsevier 2015
Materias:	Original Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4443294/ https://www.ncbi.nlm.nih.gov/pubmed/26042203 http://dx.doi.org/10.1016/j.molmet.2015.04.001

Ejemplares similares

Monoamine Oxidase is a Major Determinant of Redox Balance in Human Atrial Myocardium and is Associated With Postoperative Atrial Fibrillation
por: Anderson, Ethan J., et al.
Publicado: (2014)

Potential for Improved Glycemic Control with Dietary Momordica charantia in Patients with Insulin Resistance and Pre-Diabetes
por: Efird, Jimmy T., et al.
Publicado: (2014)

Immediate impact of coronary artery bypass graft surgery on regional myocardial perfusion: Results from the Collaborative Pilot Study to Determine the Correlation Between Intraoperative Observations Using Spy Near-Infrared Imaging and Cardiac Catheterization Laboratory Physiological Assessment of Lesion Severity
por: Buch, Ashesh N., et al.
Publicado: (2022)

Unrepaired Transitional Atrioventricular Septal Defect in a 52-Year-Old Patient
por: Abdelhaleem, Ahmed, et al.
Publicado: (2022)

The “Goldilocks Zone” from a redox perspective—Adaptive vs. deleterious responses to oxidative stress in striated muscle
por: Alleman, Rick J., et al.
Publicado: (2014)

Grand Challenge: Understanding Survival Paradoxes in Epidemiology
por: Efird, Jimmy T., et al.
Publicado: (2013)

Smoking and dietary inadequacy among Inuvialuit women of child bearing age in the Northwest Territories, Canada
por: Kolahdooz, Fariba, et al.
Publicado: (2013)

Increased risk of atrial fibrillation among patients undergoing coronary artery bypass graft surgery while receiving nitrates and antiplatelet agents
por: Efird, Jimmy T., et al.
Publicado: (2018)

GPX4 and GPX7 Over-Expression in Human Hepatocellular Carcinoma Tissues
por: Guerriero, E., et al.
Publicado: (2015)

The Effect of Race and Chronic Obstructive Pulmonary Disease on Long-Term Survival after Coronary Artery Bypass Grafting
por: Efird, Jimmy T., et al.
Publicado: (2013)

Factors Associated with Discharge to a Skilled Nursing Facility after Transcatheter Aortic Valve Replacement Surgery
por: Horne, Carolyn E., et al.
Publicado: (2018)

Translational Regulation of GPx-1 and GPx-4 by the mTOR Pathway
por: Reinke, Emily N., et al.
Publicado: (2014)

Racial Differences in Survival among Hemodialysis Patients after Coronary Artery Bypass Grafting
por: Efird, Jimmy T., et al.
Publicado: (2013)

Risk-Adjusted Survival after Coronary Artery Bypass Grafting: Implications for Quality Improvement
por: Efird, Jimmy T., et al.
Publicado: (2014)

Discharge β-Blocker Use and Race after Coronary Artery Bypass Grafting
por: O’Neal, Wesley T., et al.
Publicado: (2014)

Long-Term Mortality of 306,868 Patients with Multi-Vessel Coronary Artery Disease: CABG versus PCI
por: Efird, Jimmy T., et al.
Publicado: (2013)

Simultaneous detection of the enzyme activities of GPx1 and GPx4 guide optimization of selenium in cell biological experiments
por: Stolwijk, Jeffrey M., et al.
Publicado: (2020)

PTEN haploinsufficiency and hemangiosarcoma
Publicado: (2012)

Conditional haploinsufficiency of the retinoblastoma tumor suppressor gene
por: Ishak, Charles A, et al.
Publicado: (2014)

Increased Coronary Artery Disease Severity in Black Women Undergoing Coronary Bypass Surgery
por: Efird, Jimmy T., et al.
Publicado: (2015)

Chosen Antioxidant Enzymes GPx4 and GPx8 in Human Colorectal Carcinoma: Study of the Slovak Population
por: Pavliuk-Karachevtseva, Andriana, et al.
Publicado: (2022)

An Efficient Gatekeeper Algorithm for Detecting GxE
por: Efird, Jimmy T.
Publicado: (2010)

Season of Birth and Risk for Adult Onset Glioma
por: Efird, Jimmy T.
Publicado: (2010)

Blocked Randomization with Randomly Selected Block Sizes
por: Efird, Jimmy
Publicado: (2011)

Computing Power and Sample Size for Informational Odds Ratio (†)
por: Efird, Jimmy T.
Publicado: (2013)

Calls for Stricter Legislation and Fear in the European Immigrant Community: Reflections of the Public Charge Debate Ongoing in the United States: Comment on "A Crisis of Humanitarianism: Refugees at the Gates of Europe"
por: Efird, Jimmy
Publicado: (2019)

Goldilocks Rounding: Achieving Balance Between Accuracy and Parsimony in the Reporting of Relative Effect Estimates
por: Efird, Jimmy T
Publicado: (2021)

Operational intricacies of sequencing-based surveillance in developing countries
por: Efird, Jimmy T.
Publicado: (2022)

PLIN1 Haploinsufficiency Is Not Associated With Lipodystrophy
por: Laver, Thomas W, et al.
Publicado: (2018)

Animal Viruses, Bacteria, and Cancer: A Brief Commentary
por: Efird, Jimmy T., et al.
Publicado: (2014)

Increased Long-Term Mortality among Black CABG Patients Receiving Preoperative Inotropic Agents
por: Efird, Jimmy T., et al.
Publicado: (2015)

HIPred: an integrative approach to predicting haploinsufficient genes
por: Shihab, Hashem A, et al.
Publicado: (2017)

Sinusoidal Cox Regression—A Rare Cancer Example
por: Efird, Jimmy Thomas
Publicado: (2010)

Two-Carbon Homologation of Aldehydes and Ketones to α,β-Unsaturated Aldehydes
por: Petroski, Richard J., et al.
Publicado: (2011)

Epididymis Response Partly Compensates for Spermatozoa Oxidative Defects in snGPx4 and GPx5 Double Mutant Mice
por: Noblanc, Anaïs, et al.
Publicado: (2012)

GPX7 Is Targeted by miR-29b and GPX7 Knockdown Enhances Ferroptosis Induced by Erastin in Glioma
por: Zhou, Yan, et al.
Publicado: (2022)

Glutathione Peroxidase gpx1 to gpx8 Genes Expression in Experimental Brain Tumors Reveals Gender-Dependent Patterns
por: Cueto-Ureña, Cristina, et al.
Publicado: (2023)

Development of an assay pipeline for the discovery of novel small molecule inhibitors of human glutathione peroxidases GPX1 and GPX4
por: Cheff, Dorian M., et al.
Publicado: (2023)

Smad4 haploinsufficiency: a matter of dosage
por: Alberici, Paola, et al.
Publicado: (2008)

Sox9-Haploinsufficiency Causes Glucose Intolerance in Mice
por: Dubois, Claire L., et al.
Publicado: (2011)

Cannot write session to /tmp/vufind_sessions/sess_9rstfqbqi2mq76ol2d8e762ifp