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Most partial domains in proteins are alignment and annotation artifacts

BACKGROUND: Protein domains are commonly used to assess the functional roles and evolutionary relationships of proteins and protein families. Here, we use the Pfam protein family database to examine a set of candidate partial domains. Pfam protein domains are often thought of as evolutionarily indiv...

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Detalles Bibliográficos
Autores principales: Triant, Deborah A, Pearson, William R
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2015
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4443539/
https://www.ncbi.nlm.nih.gov/pubmed/25976240
http://dx.doi.org/10.1186/s13059-015-0656-7