The C-terminal region of the motor protein MCAK controls its structure and activity through a conformational switch

The precise regulation of microtubule dynamics is essential during cell division. The kinesin-13 motor protein MCAK is a potent microtubule depolymerase. The divergent non-motor regions flanking the ATPase domain are critical in regulating its targeting and activity. However, the molecular basis for...

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Detalles Bibliográficos
Autores principales: Talapatra, Sandeep K, Harker, Bethany, Welburn, Julie PI
Formato: Online Artículo Texto
Lenguaje:English
Publicado: eLife Sciences Publications, Ltd 2015
Materias:
Biochemistry
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4443670/
https://www.ncbi.nlm.nih.gov/pubmed/25915621
http://dx.doi.org/10.7554/eLife.06421

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4443670/
https://www.ncbi.nlm.nih.gov/pubmed/25915621
http://dx.doi.org/10.7554/eLife.06421

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