Eriocalyxin B Inhibits STAT3 Signaling by Covalently Targeting STAT3 and Blocking Phosphorylation and Activation of STAT3

Activated STAT3 plays an important role in oncogenesis by stimulating cell proliferation and resisting apoptosis. STAT3 therefore is an attractive target for cancer therapy. We have screened a traditional Chinese herb medicine compound library and found Eriocalyxin B (EB), a diterpenoid from Isodon...

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Detalles Bibliográficos
Autores principales: Yu, Xiaokui, He, Li, Cao, Peng, Yu, Qiang
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2015
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4444003/
https://www.ncbi.nlm.nih.gov/pubmed/26010889
http://dx.doi.org/10.1371/journal.pone.0128406

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4444003/
https://www.ncbi.nlm.nih.gov/pubmed/26010889
http://dx.doi.org/10.1371/journal.pone.0128406

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