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Tumor Treating Fields Perturb the Localization of Septins and Cause Aberrant Mitotic Exit

The anti-tumor effects of chemotherapy and radiation are thought to be mediated by triggering G(1)/S or G(2)/M cell cycle checkpoints, while spindle poisons, such as paclitaxel, block metaphase exit by initiating the spindle assembly checkpoint. In contrast, we have found that 150 kilohertz (kHz) al...

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Detalles Bibliográficos
Autores principales: Gera, Nidhi, Yang, Aaron, Holtzman, Talia S., Lee, Sze Xian, Wong, Eric T., Swanson, Kenneth D.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2015
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4444126/
https://www.ncbi.nlm.nih.gov/pubmed/26010837
http://dx.doi.org/10.1371/journal.pone.0125269