Quantifying the cumulative effect of low-penetrance genetic variants on breast cancer risk

Many common diseases have a complex genetic basis in which large numbers of genetic variations combine with environmental factors to determine risk. However, quantifying such polygenic effects has been challenging. In order to address these difficulties we developed a global measure of the informati...

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Detalles Bibliográficos
Autores principales: Smyth, Conor, Špakulová, Iva, Cotton-Barratt, Owen, Rafiq, Sajjad, Tapper, William, Upstill-Goddard, Rosanna, Hopper, John L, Makalic, Enes, Schmidt, Daniel F, Kapuscinski, Miroslav, Fliege, Jörg, Collins, Andrew, Brodzki, Jacek, Eccles, Diana M, MacArthur, Ben D
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BlackWell Publishing Ltd 2015
Materias:
Original Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4444159/
https://www.ncbi.nlm.nih.gov/pubmed/26029704
http://dx.doi.org/10.1002/mgg3.129

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4444159/
https://www.ncbi.nlm.nih.gov/pubmed/26029704
http://dx.doi.org/10.1002/mgg3.129

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