Inhibition of T-Type Voltage Sensitive Calcium Channel Reduces Load-Induced OA in Mice and Suppresses the Catabolic Effect of Bone Mechanical Stress on Chondrocytes

Voltage-sensitive calcium channels (VSCC) regulate cellular calcium influx, one of the earliest responses to mechanical stimulation in osteoblasts. Here, we postulate that T-type VSCCs play an essential role in bone mechanical response to load and participate in events leading to the pathology of lo...

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Detalles Bibliográficos
Autores principales: Srinivasan, Padma P., Parajuli, Ashutosh, Price, Christopher, Wang, Liyun, Duncan, Randall L., Kirn-Safran, Catherine B.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2015
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4444170/
https://www.ncbi.nlm.nih.gov/pubmed/26011709
http://dx.doi.org/10.1371/journal.pone.0127290

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4444170/
https://www.ncbi.nlm.nih.gov/pubmed/26011709
http://dx.doi.org/10.1371/journal.pone.0127290

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