Chronic Hyperglycemia Induces Trans-Differentiation of Human Pancreatic Stellate Cells and Enhances the Malignant Molecular Communication with Human Pancreatic Cancer Cells

BACKGROUND: Diabetes mellitus is linked to pancreatic cancer. We hypothesized a role for pancreatic stellate cells (PSC) in the hyperglycemia induced deterioration of pancreatic cancer and therefore studied two human cell lines (RLT-PSC, T3M4) in hyperglycemic environment. METHODOLOGY/PRINCIPAL FIND...

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Detalles Bibliográficos
Autores principales: Kiss, Katalin, Baghy, Kornélia, Spisák, Sándor, Szanyi, Szilárd, Tulassay, Zsolt, Zalatnai, Attila, Löhr, J.-Matthias, Jesenofsky, Ralf, Kovalszky, Ilona, Firneisz, Gábor
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2015
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4444240/
https://www.ncbi.nlm.nih.gov/pubmed/26010611
http://dx.doi.org/10.1371/journal.pone.0128059

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4444240/
https://www.ncbi.nlm.nih.gov/pubmed/26010611
http://dx.doi.org/10.1371/journal.pone.0128059

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