Structural Basis for the Inhibition of Helicobacter pylori α-Carbonic Anhydrase by Sulfonamides

Periplasmic α-carbonic anhydrase of Helicobacter pylori (HpαCA), an oncogenic bacterium in the human stomach, is essential for its acclimation to low pH. It catalyses the conversion of carbon dioxide to bicarbonate using Zn(II) as the cofactor. In H. pylori, Neisseria spp., Brucella suis and Strepto...

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Detalles Bibliográficos
Autores principales: Modakh, Joyanta K., Liu, Yu C., Machuca, Mayra A., Supuran, Claudiu T., Roujeinikova, Anna
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2015
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4444264/
https://www.ncbi.nlm.nih.gov/pubmed/26010545
http://dx.doi.org/10.1371/journal.pone.0127149

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4444264/
https://www.ncbi.nlm.nih.gov/pubmed/26010545
http://dx.doi.org/10.1371/journal.pone.0127149

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