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The Fitness Consequences of Aneuploidy Are Driven by Condition-Dependent Gene Effects

Aneuploidy is a hallmark of tumor cells, and yet the precise relationship between aneuploidy and a cell’s proliferative ability, or cellular fitness, has remained elusive. In this study, we have combined a detailed analysis of aneuploid clones isolated from laboratory-evolved populations of Saccharo...

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Detalles Bibliográficos
Autores principales:	Sunshine, Anna B., Payen, Celia, Ong, Giang T., Liachko, Ivan, Tan, Kean Ming, Dunham, Maitreya J.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Public Library of Science 2015
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4444335/ https://www.ncbi.nlm.nih.gov/pubmed/26011532 http://dx.doi.org/10.1371/journal.pbio.1002155

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