Opioid-induced hyperalgesia in chronic pain patients and the mitigating effects of gabapentin

Chronic pain patients receiving opioid drugs are at risk for opioid-induced hyperalgesia (OIH), wherein opioid pain medication leads to a paradoxical pain state. OIH involves central sensitization of primary and secondary afferent neurons in the dorsal horn and dorsal root ganglion, similar to neuro...

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Detalles Bibliográficos
Autores principales: Stoicea, Nicoleta, Russell, Daric, Weidner, Greg, Durda, Michael, Joseph, Nicholas C., Yu, Jeffrey, Bergese, Sergio D.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2015
Materias:
Pharmacology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4444749/
https://www.ncbi.nlm.nih.gov/pubmed/26074817
http://dx.doi.org/10.3389/fphar.2015.00104

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4444749/
https://www.ncbi.nlm.nih.gov/pubmed/26074817
http://dx.doi.org/10.3389/fphar.2015.00104

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