Effects of drug-resistant mutations on the dynamic properties of HIV-1 protease and inhibition by Amprenavir and Darunavir

Molecular dynamics simulations are performed to investigate the dynamic properties of wild-type HIV-1 protease and its two multi-drug-resistant variants (Flap + (L10I/G48V/I54V/V82A) and Act (V82T/I84V)) as well as their binding with APV and DRV inhibitors. The hydrophobic interactions between flap...

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Detalles Bibliográficos
Autores principales: Yu, Yuqi, Wang, Jinan, Shao, Qiang, Shi, Jiye, Zhu, Weiliang
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2015
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4444956/
https://www.ncbi.nlm.nih.gov/pubmed/26012849
http://dx.doi.org/10.1038/srep10517

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4444956/
https://www.ncbi.nlm.nih.gov/pubmed/26012849
http://dx.doi.org/10.1038/srep10517

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