Enthalpy-entropy compensation at play in human copper ion transfer

Copper (Cu) is an essential trace element but toxic in free form. After cell uptake, Cu is transferred, via direct protein-protein interactions, from the chaperone Atox1 to the Wilson disease protein (WD) for incorporation into Cu-dependent enzymes. Cu binds to a conserved C(1)XXC(2) motif in the ch...

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Detalles Bibliográficos
Autores principales: Niemiec, Moritz S., Dingeldein, Artur P. G., Wittung-Stafshede, Pernilla
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2015
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4444973/
https://www.ncbi.nlm.nih.gov/pubmed/26013029
http://dx.doi.org/10.1038/srep10518

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4444973/
https://www.ncbi.nlm.nih.gov/pubmed/26013029
http://dx.doi.org/10.1038/srep10518

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