The human ankyrin 1 promoter insulator sustains gene expression in a β-globin lentiviral vector in hematopoietic stem cells

Lentiviral vectors designed for the treatment of the hemoglobinopathies require the inclusion of regulatory and strong enhancer elements to achieve sufficient expression of the β-globin transgene. Despite the inclusion of these elements, the efficacy of these vectors may be limited by transgene sile...

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Detalles Bibliográficos
Autores principales: Romero, Zulema, Campo-Fernandez, Beatriz, Wherley, Jennifer, Kaufman, Michael L, Urbinati, Fabrizia, Cooper, Aaron R, Hoban, Megan D, Baldwin, Kismet M, Lumaquin, Dianne, Wang, Xiaoyan, Senadheera, Shantha, Hollis, Roger P, Kohn, Donald B
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2015
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4445009/
https://www.ncbi.nlm.nih.gov/pubmed/26029723
http://dx.doi.org/10.1038/mtm.2015.12

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4445009/
https://www.ncbi.nlm.nih.gov/pubmed/26029723
http://dx.doi.org/10.1038/mtm.2015.12

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