Amyloid Precursor Protein (APP) Affects Global Protein Synthesis in Dividing Human Cells

Hypoxic non‐small cell lung cancer (NSCLC) is dependent on Notch‐1 signaling for survival. Targeting Notch‐1 by means of γ‐secretase inhibitors (GSI) proved effective in killing hypoxic NSCLC. Post‐mortem analysis of GSI‐treated, NSCLC‐burdened mice suggested enhanced phosphorylation of 4E‐BP1 at th...

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Detalles Bibliográficos
Autores principales: Sobol, Anna, Galluzzo, Paola, Liang, Shuang, Rambo, Brittany, Skucha, Sylvia, Weber, Megan J., Alani, Sara, Bocchetta, Maurizio
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2015
Materias:
Original Research Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4445069/
https://www.ncbi.nlm.nih.gov/pubmed/25283437
http://dx.doi.org/10.1002/jcp.24835

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4445069/
https://www.ncbi.nlm.nih.gov/pubmed/25283437
http://dx.doi.org/10.1002/jcp.24835

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