Cargando…

Full length and protease domain activity of chikungunya virus nsP2 differ from other alphavirus nsP2 proteases in recognition of small peptide substrates

Alphavirus nsP2 proteins are multifunctional and essential for viral replication. The protease role of nsP2 is critical for virus replication as only the virus protease activity is used for processing of the viral non-structural polypeptide. Chikungunya virus is an emerging disease problem that is b...

Descripción completa

Detalles Bibliográficos
Autores principales:	Saisawang, Chonticha, Sillapee, Pornpan, Sinsirimongkol, Kwanhathai, Ubol, Sukathida, Smith, Duncan R., Ketterman, Albert J.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Portland Press Ltd. 2015
Materias:	Original Paper
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4445351/ https://www.ncbi.nlm.nih.gov/pubmed/26182358 http://dx.doi.org/10.1042/BSR20150086

Ejemplares similares

Chikungunya nsP2 protease is not a papain-like cysteine protease and the catalytic dyad cysteine is interchangeable with a proximal serine
por: Saisawang, Chonticha, et al.
Publicado: (2015)

Expression and biochemical characterization of nsP2 cysteine protease of Chikungunya virus
por: Pastorino, Boris A.M., et al.
Publicado: (2008)

1,3-Thiazolbenzamide Derivatives as Chikungunya Virus nsP2 Protease Inhibitors
por: Ivanova, Larisa, et al.
Publicado: (2021)

Chikungunya virus nsP1 interacts directly with nsP2 and modulates its ATPase activity
por: Kumar, Sameer, et al.
Publicado: (2018)

Interactions of Alphavirus nsP3 Protein with Host Proteins
por: Lark, Tyler, et al.
Publicado: (2018)

Molecular Modeling and Docking Study to Elucidate Novel Chikungunya Virus nsP2 Protease Inhibitors
por: Agarwal, T., et al.
Publicado: (2015)

Structural basis and dynamics of Chikungunya alphavirus RNA capping by nsP1 capping pores
por: Jones, Rhian, et al.
Publicado: (2023)

A model to study the inhibition of nsP2B-nsP3 protease of dengue virus with imidazole, oxazole, triazole thiadiazole, and thiazolidine based scaffolds
por: Vishvakarma, Vijay Kumar, et al.
Publicado: (2019)

Analysis of chikungunya virus proteins reveals that non-structural proteins nsP2 and nsP3 exhibit RNA interference (RNAi) suppressor activity
por: Mathur, Kalika, et al.
Publicado: (2016)

Sindbis Virus nsP2 Endopeptidase
por: Strauss, Ellen G., et al.
Publicado: (2013)

Capping pores of alphavirus nsP1 gate membranous viral replication factories
por: Jones, Rhian, et al.
Publicado: (2020)

nsP4 Is a Major Determinant of Alphavirus Replicase Activity and Template Selectivity
por: Lello, Laura Sandra, et al.
Publicado: (2021)

NTPase and 5′-RNA Triphosphatase Activities of Chikungunya Virus nsP2 Protein
por: Karpe, Yogesh A., et al.
Publicado: (2011)

Chikungunya virus infectivity, RNA replication and non-structural polyprotein processing depend on the nsP2 protease’s active site cysteine residue
por: Rausalu, Kai, et al.
Publicado: (2016)

Development of nsP2 protease based cell free high throughput screening assay for evaluation of inhibitors against emerging Chikungunya virus
por: Saha, Amrita, et al.
Publicado: (2018)

Expression of Alphavirus Nonstructural Protein 2 (nsP2) in Mosquito Cells Inhibits Viral RNA Replication in Both a Protease Activity-Dependent and -Independent Manner
por: Cherkashchenko, Liubov, et al.
Publicado: (2022)

Characterization of the cysteine protease domain of Semliki Forest virus replicase protein nsP2 by in vitro mutagenesis
por: Golubtsov, Andrey, et al.
Publicado: (2006)

Discovery of in silico hits targeting the nsP3 macro domain of chikungunya virus
por: Nguyen, Phuong T. V., et al.
Publicado: (2014)

The Enigmatic Alphavirus Non-Structural Protein 3 (nsP3) Revealing Its Secrets at Last
por: Götte, Benjamin, et al.
Publicado: (2018)

Computational approach to study the synthesis of noscapine and potential of stereoisomers against nsP3 protease of CHIKV
por: Singh, Prashant, et al.
Publicado: (2019)

Both ADP-Ribosyl-Binding and Hydrolase Activities of the Alphavirus nsP3 Macrodomain Affect Neurovirulence in Mice
por: Abraham, Rachy, et al.
Publicado: (2020)

Multiple roles of the non-structural protein 3 (nsP3) alphavirus unique domain (AUD) during Chikungunya virus genome replication and transcription
por: Gao, Yanni, et al.
Publicado: (2019)

MBZM-N-IBT, a Novel Small Molecule, Restricts Chikungunya Virus Infection by Targeting nsP2 Protease Activity In Vitro, In Vivo, and Ex Vivo
por: De, Saikat, et al.
Publicado: (2022)

Mosquito Rasputin interacts with chikungunya virus nsP3 and determines the infection rate in Aedes albopictus
por: Fros, Jelke J., et al.
Publicado: (2015)

The viral capping enzyme nsP1: a novel target for the inhibition of chikungunya virus infection
por: Delang, L., et al.
Publicado: (2016)

Pyrimidone inhibitors targeting Chikungunya Virus nsP3 macrodomain by fragment-based drug design
por: Zhang, Sixue, et al.
Publicado: (2021)

Lineage replacement accompanying duplication and rapid fixation of an RNA element in the nsP3 gene in a species of alphavirus
por: Aaskov, John, et al.
Publicado: (2011)

Identification of the active site residues in the nsP2 proteinase of sindbis virus
por: Strauss, Ellen G., et al.
Publicado: (1992)

Mono-ADP-ribosylation by PARP10 inhibits Chikungunya virus nsP2 proteolytic activity and viral replication
por: Krieg, Sarah, et al.
Publicado: (2023)

SH3 Domain-Mediated Recruitment of Host Cell Amphiphysins by Alphavirus nsP3 Promotes Viral RNA Replication
por: Neuvonen, Maarit, et al.
Publicado: (2011)

Combined structural, biochemical and cellular evidence demonstrates that both FGDF motifs in alphavirus nsP3 are required for efficient replication
por: Schulte, Tim, et al.
Publicado: (2016)

Conserved motifs in the hypervariable domain of chikungunya virus nsP3 required for transmission by Aedes aegypti mosquitoes
por: Göertz, Giel P., et al.
Publicado: (2018)

Evaluation of the Antiviral Potential of Halogenated Dihydrorugosaflavonoids and Molecular Modeling with nsP3 Protein of Chikungunya Virus (CHIKV)
por: Puranik, Ninad V., et al.
Publicado: (2019)

Insights into the role of the cobalt(III)-thiosemicarbazone complex as a potential inhibitor of the Chikungunya virus nsP4
por: Martins, Daniel Oliveira Silva, et al.
Publicado: (2022)

Targeted in vitro gene silencing of E2 and nsP1 genes of chikungunya virus by biocompatible zeolitic imidazolate framework
por: Tagore, Rajarshee, et al.
Publicado: (2022)

Crystal structures of alphavirus nonstructural protein 4 (nsP4) reveal an intrinsically dynamic RNA-dependent RNA polymerase fold
por: Tan, Yaw Bia, et al.
Publicado: (2022)

A Sensitive and Robust High-Throughput Screening Assay for Inhibitors of the Chikungunya Virus nsP1 Capping Enzyme
por: Bullard-Feibelman, Kristen M., et al.
Publicado: (2016)

Mutation of CD2AP and SH3KBP1 Binding Motif in Alphavirus nsP3 Hypervariable Domain Results in Attenuated Virus
por: Mutso, Margit, et al.
Publicado: (2018)

Alphavirus Evasion of Zinc Finger Antiviral Protein (ZAP) Correlates with CpG Suppression in a Specific Viral nsP2 Gene Sequence
por: Nguyen, LeAnn P., et al.
Publicado: (2023)

Chikungunya Virus Overcomes Polyamine Depletion by Mutation of nsP1 and the Opal Stop Codon To Confer Enhanced Replication and Fitness
por: Mounce, Bryan C., et al.
Publicado: (2017)

Cannot write session to /tmp/vufind_sessions/sess_ahfigesmhphmkd3946r1slheb1