Skeletal muscle myotubes of the severely obese exhibit altered ubiquitin-proteasome and autophagic/lysosomal proteolytic flux

OBJECTIVE: Whole-body protein metabolism is dysregulated with obesity. Our goal was to determine if activity and expression of major protein degradation pathways are compromised specifically in human skeletal muscle with obesity. METHODS: We utilized primary Human Skeletal Muscle cell (HSkM) culture...

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Detalles Bibliográficos
Autores principales: Bollinger, Lance M., Powell, Jonathan J. S., Houmard, Joseph A., Witczak, Carol A., Brault, Jeffrey J.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2015
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4445474/
https://www.ncbi.nlm.nih.gov/pubmed/26010327
http://dx.doi.org/10.1002/oby.21081

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4445474/
https://www.ncbi.nlm.nih.gov/pubmed/26010327
http://dx.doi.org/10.1002/oby.21081

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