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Skeletal muscle myotubes of the severely obese exhibit altered ubiquitin-proteasome and autophagic/lysosomal proteolytic flux
OBJECTIVE: Whole-body protein metabolism is dysregulated with obesity. Our goal was to determine if activity and expression of major protein degradation pathways are compromised specifically in human skeletal muscle with obesity. METHODS: We utilized primary Human Skeletal Muscle cell (HSkM) culture...
Autores principales: | Bollinger, Lance M., Powell, Jonathan J. S., Houmard, Joseph A., Witczak, Carol A., Brault, Jeffrey J. |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
2015
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4445474/ https://www.ncbi.nlm.nih.gov/pubmed/26010327 http://dx.doi.org/10.1002/oby.21081 |
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