Modeling of interaction between cytochrome c and the WD domains of Apaf-1: bifurcated salt bridges underlying apoptosome assembly

BACKGROUND: Binding of cytochrome c, released from the damaged mitochondria, to the apoptotic protease activating factor 1 (Apaf-1) is a key event in the apoptotic signaling cascade. The binding triggers a major domain rearrangement in Apaf-1, which leads to oligomerization of Apaf-1/cytochrome c co...

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Detalles Bibliográficos
Autores principales: Shalaeva, Daria N., Dibrova, Daria V., Galperin, Michael Y., Mulkidjanian, Armen Y.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2015
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4445527/
https://www.ncbi.nlm.nih.gov/pubmed/26014357
http://dx.doi.org/10.1186/s13062-015-0059-4

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4445527/
https://www.ncbi.nlm.nih.gov/pubmed/26014357
http://dx.doi.org/10.1186/s13062-015-0059-4

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