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Cell cycle synchronization and BrdU incorporation as a tool to study the possible selective elimination of ErbB1 gene in the micronuclei in A549 cells

Lung cancer often exhibits molecular changes, such as the overexpression of the ErbB1 gene that encodes epidermal growth factor receptor (EGFR). ErbB1 amplification and mutation are associated with tumor aggressiveness and low response to therapy. The aim of the present study was to design a schedul...

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Detalles Bibliográficos
Autores principales: Lauand, C., Niero, E.L., Dias, V.M., Machado-Santelli, G.M.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Associação Brasileira de Divulgação Científica 2015
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4445660/
https://www.ncbi.nlm.nih.gov/pubmed/25760027
http://dx.doi.org/10.1590/1414-431X20144262