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Altered LINE-1 Methylation in Mothers of Children with Down Syndrome
Down syndrome (DS, also known as trisomy 21) most often results from chromosomal nondisjunction during oogenesis. Numerous studies sustain a causal link between global DNA hypomethylation and genetic instability. It has been suggested that DNA hypomethylation might affect the structure and dynamics...
Autores principales: | Babić Božović, Ivana, Stanković, Aleksandra, Živković, Maja, Vraneković, Jadranka, Kapović, Miljenko, Brajenović-Milić, Bojana |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Public Library of Science
2015
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4446367/ https://www.ncbi.nlm.nih.gov/pubmed/26017139 http://dx.doi.org/10.1371/journal.pone.0127423 |
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