Genome engineering of isogenic human ES cells to model autism disorders

Isogenic pluripotent stem cells are critical tools for studying human neurological diseases by allowing one to study the effects of a mutation in a fixed genetic background. Of particular interest are the spectrum of autism disorders, some of which are monogenic such as Timothy syndrome (TS); others...

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Detalles Bibliográficos
Autores principales: Martinez, Refugio A., Stein, Jason L., Krostag, Anne-Rachel F., Nelson, Angelique M., Marken, John S., Menon, Vilas, May, Ryan C., Yao, Zizhen, Kaykas, Ajamete, Geschwind, Daniel H., Grimley, Joshua S.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2015
Materias:
Methods Online
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4446412/
https://www.ncbi.nlm.nih.gov/pubmed/25765640
http://dx.doi.org/10.1093/nar/gkv164

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4446412/
https://www.ncbi.nlm.nih.gov/pubmed/25765640
http://dx.doi.org/10.1093/nar/gkv164

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