Local DNA dynamics shape mutational patterns of mononucleotide repeats in human genomes

Single base substitutions (SBSs) and insertions/deletions are critical for generating population diversity and can lead both to inherited disease and cancer. Whereas on a genome-wide scale SBSs are influenced by cellular factors, on a fine scale SBSs are influenced by the local DNA sequence-context,...

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Detalles Bibliográficos
Autores principales: Bacolla, Albino, Zhu, Xiao, Chen, Hanning, Howells, Katy, Cooper, David N., Vasquez, Karen M.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2015
Materias:
Genomics
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4446427/
https://www.ncbi.nlm.nih.gov/pubmed/25897114
http://dx.doi.org/10.1093/nar/gkv364

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4446427/
https://www.ncbi.nlm.nih.gov/pubmed/25897114
http://dx.doi.org/10.1093/nar/gkv364

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